期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 13, 期 -, 页码 4925-4932出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3051
关键词
JAK; STAT; SHP2; cytokine; signal transduction; hematopoiesis
资金
- NHLBI NIH HHS [HL068212, R01 HL068212, HL082670, R21 HL082670, R01 HL068212-05A2, R21 HL082670-02] Funding Source: Medline
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial in controlling cellular activities in response to extracellular cytokines. Dysfunctions of the JAK/STAT pathway result in various hematopoietic and immune disorders. The central events in regulating this pathway are tyrosine phosphorylation and dephosphorylation of the signaling components, which are carried out by protein tyrosine kinases and protein tyrosine phosphatases (PTP), respectively. Here, we review recent advances in the regulatory roles of PTPs, in particular, SHP2 phosphatase, in the JAK/STAT signaling pathway.
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