期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 13, 期 -, 页码 4827-4837出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3042
关键词
invariant natural killer T cells; immune regulation; autoimmune disease; cytokines; dendritic cells; regulatory T cells; review
Invariant NKT cells are important regulators of T cell immunity and autoimmunity. In this review we describe evidence that supports their regulatory role in the prevention of autoimmune disease. Moreover, we will discuss the current knowledge on iNKT cell biology, antigen recognition, acquisition of a specific cytokine profile, and mechanism of action that suggest a key role for iNKT cells as negative regulators of autoimmune diseases.
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