期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 13, 期 -, 页码 4198-4217出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3000
关键词
endothelium-derived hyperpolarizing factor; EDHF; endothelium-derived contracting factor; EDCF; endothelin-1; ET; nitric oxide; Connexins; TRP channels; Na+-K+-ATPase; lipoxygenase; cytochrome P450 monoxygenases; heme oxygenase; carbon monoxide; C-type natriuretic peptide; hydrogen peroxide
The endothelium can elicit relaxations and contractions of the underlying smooth muscle cells. It does so by releasing vasodilator (EDRF) and vasoconstrictor (EDCF) mediators. Among the diffusible endothelial factors nitric oxide (NO) plays a key role, particularly in large blood vessels. This chapter briefly reviews the interactions between NO and the other vasomotor signals released by the endothelial cells.
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