期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 13, 期 -, 页码 5905-5915出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3125
关键词
BRCT domains; phosphopeptide binding; BRCA1; BACH1; protein-protein interactions; CtIP; Abraxas; RAP80; DNA damage; DNA repair; phosphoserine binding domain; cancer mutations; tumor suppressor; cell cycle; crystal structure; signal transduction; phosphorylation; protein folding; sequence homology; missense mutations; Review
The BRCA1 C-terminus (BRCT) domains are essential for the tumor suppressor function of BRCA1, and have been found in a variety of proteins from bacteria to men. Recent studies demonstrate that the BRCT domain constitutes a novel phosphopeptide binding region. In this review we seek to discuss the recent biochemical and structural data that have helped elucidate the molecular basis of BRCT domain function and BRCT-mediated interactions, with special emphasis on the role of phospho-specific interactions in key networks that regulate DNA repair. Finally we offer predictions on additional phospho-interacting BRCT domains and potential in vivo binding sites for several BRCT domains.
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