期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 13, 期 -, 页码 2353-2365出版社
BIOSCIENCE RESEARCH INST-BRI
DOI: 10.2741/2839
关键词
Alzheimer's disease; beta-amyloid; dementia; hypertension; renin-angiotensin system; angiotensin II; angiotensin IV; ACE inhibitor; angiotensin-receptor blocker; cognitive function; prevention; review
Alzheimer's disease, which is the most common cause of dementia, is traditionally thought to be a neurodegenerative disorder and not of vascular origin. However, there is a growing body of evidence suggesting an association between vascular risk factors and Alzheimer's disease. Several epidemiological studies have shown that high mid-life blood pressure is related to the development of Alzheimer's disease in later life. Furthermore, the use of some kinds of antihypertensive medication has been suggested to reduce the incidence of dementia including Alzheimer's disease. Recent findings indicate that the brain has its own renin-angiotensin system, which mediates several physiological and pathological brain functions. The neurobiological links between the renin-angiotensin system and Alzheimer's disease have been investigated and become a source of interest in the pathogenesis of the disease. This review describes the relation between the renin-angiotensin system, hypertension and Alzheimer's disease, and also discusses the potential use of antihypertensive drugs acting via the renin-angiotensin system in the treatment and prevention of the disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据