期刊
FREE RADICAL RESEARCH
卷 48, 期 8, 页码 898-906出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2014.920955
关键词
diabetes; myocardium; mitochondrial dysfunction; autophagy; EGCG
资金
- National Natural Science Foundation of China [31070740]
- New Century Excellent Talents in University
- National Twelfth FiveYear Plan for Science & Technology Support
- Fundamental Research Funds for the Central Universities
- Shaanxi province science and technology research and development program [2013K12-01-10]
Type 2 diabetes mellitus (T2DM) is a risk factor for heart disease. However, the mechanisms of T2DM involvement in cardiac complications are still unclear. In the present study, we investigated mitochondria-related mechanisms underlying the pathogenesis of myocardial disorders in diabetic Goto-Kakizaki (GK) rats. We found that remarkable myocardial mitochondrial deficiency and dysfunction as well as oxidative stress occurred in the heart of GK rats. In addition, our results suggested that the loss of mitochondria was in response to elevated autophagy and upstream FoxO factors in diabetic myocardium. More importantly, (-)-epigallocatechin-3-gallate (EGCG), a polyphenol derived from green tea, successfully improved mitochondrial function and autophagy in the heart of GK rats. Our findings revealed that diabetes-associated myocardial mitochondrial deficiency and dysfunction was associated with enhanced autophagy in myocardium, and EGCG might be a potential agent in preventing and treating myocardial disorders involved in diabetes.
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