期刊
FREE RADICAL RESEARCH
卷 46, 期 6, 页码 726-739出版社
INFORMA HEALTHCARE
DOI: 10.3109/10715762.2012.669836
关键词
Non-steroidal antiinflammatory drugs; D-serine; inflammation; apoptosis
资金
- Ege University Scientific Research Foundation [09/ECZ/019]
- Turkish Scientific and Technological Council (TUBITAK)
Mefenamic acid, a non-steroidal antiinflammatory drug (NSAID), directly and dose-dependently exhibits neuroprotective activity. In our study, we investigated the effects of mefenamic acid against D-serine on oxidative stress in the hippocampus, cortex and cerebellum of rats. Furthermore, the potential inflammatory and apoptotic effects of D-serine and potential protective effect of mefenamic acid were determined at mRNA and protein levels of TNF-alpha, IL-1 beta, Bcl-2 and Bax. We found that D-serine significantly increased oxidative stress, levels of inflammation-and apoptosis-related molecules in a region specific manner. Mefenamic acid treatment provided signifi cant protection against the elevation of lipid peroxidation, protein oxidation, levels of TNF-alpha, IL-1 beta and Bax. As a conclusion, we suggest that D-serine, as a potential neurodegenerative agent, may have a pivotal role in the regulation of oxidative stress, inflammation and apoptosis; and NSAIDs, such as mefenamic acid, may assist other therapeutics in treating disorders where D-serine-induced neurotoxic mechanisms are involved in.
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