期刊
FREE RADICAL RESEARCH
卷 45, 期 11-12, 页码 1379-1387出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2011.629199
关键词
free radicals; resveratrol; antioxidant; lipid peroxidation; DNA oxidation
资金
- National Natural Science Foundation of China [21002047]
- Ministry of Education of China [20100211110027]
- Lanzhou University [lzujbky-2009-73]
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a naturally occurring polyphenol widely distributed in food and dietary plants. This phytochemical has been intensively studied as an efficient antioxidant and anticancer agent, and a variety of substituted stilbenes have been developed in order to improve the potency of resveratrol. In this work, we described the synthesis of 3,4,4'-trihydroxy-trans-stilbene (3,4,4'-THS), an analogue of resveratrol, and studied its antioxidant and cytotoxic activity in vitro. 3,4,4'-THS was much more efficient than resveratrol in protecting against free radical-induced lipid peroxidation, photo-sensitized DNA oxidative damage, and free radical-induced hemolysis of human red blood cells. More potent growth inhibition in cultured human leukemia cells (HL-60) was also observed for 3,4,4'-THS. The relationship between the antioxidant efficiency and cytotoxic activity was discussed, with the emphasis on inhibition of the free radical enzyme ribonucleotide reductase by antioxidants. The result that this subtle structure modification of resveratrol drastically improves its bioactivity provides important strategy to develop novel resveratrol-based molecules.
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