期刊
FREE RADICAL RESEARCH
卷 43, 期 6, 页码 622-628出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760902942816
关键词
Tomato; lycopene; isoprostanes; HETEs; 8OHdG; oxidative stress
资金
- Biomedical Research Council [03/1/21/18/213]
This study investigated the effect of a single dose of tomato sauce on healthy male volunteers in a randomized crossover study. Healthy male subjects (n = 10) were enrolled. Placebo (rice and olive oil) or tomato (tomato sauce, rice and olive oil) meals were provided to the volunteers. Blood and urine samples were taken before consumption of meal (0 h) and 2, 4, 6, 24 and 48 h after meal. Consumption of tomato sauce increased plasma lycopene level by 5-22%, with a maximum level at 24 h (pB < 0.01) after the meal. Levels of plasma F-2-isoprostanes, hydroxyeicosatetraenoic acid products, allantoin and urinary 8-hydroxy-2'-deoxyguanosine did not change after either meal, but urinary F-2-isoprostanes (pB < 0.05) significantly decreased at 48 h compared to 0 h after the tomato sauce meal. This study showed that a single dose of tomato sauce meal had only a limited antioxidant effect in vivo.
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