期刊
FREE RADICAL RESEARCH
卷 43, 期 9, 页码 828-835出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760903071664
关键词
Exercise; L-citrulline; polymorphonuclear neutrophils; nitric oxide; malondialdehyde
资金
- Spanish Ministry of Science and Education [DEP2005-00238-CO4-03/EQUI, DPS200807033-C03-03]
Seventeen volunteer male professional cyclists were randomly assigned to control or supplemented (6 g L-citrulline-malate) groups and participated in a cycling stage. Blood samples were taken in basal conditions, after the race and 3 h post-race. Citrulline supplementation significantly increased plasma concentration of both arginine and citrulline after the stage only in the supplemented group. Polymorphonuclear neutrophils (PMNs) from controls responded to exercise with a progressive decrease in ROS production. Supplemented PMNs significantly increased ROS production after exercise compared to basal values and diminished to values lower than basal at recovery. PMN nitrite concentration was significantly higher after exercise and recovery only in the supplemented group. Markers of oxidative damageCK, LDH, malondialdehydeand DNA damage remained unchanged in both groups. In conclusion, oral L-citrulline administration previous to a cycling stage increases plasma arginine availability for NO synthesis and PMNs priming for oxidative burst without oxidative damage.
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