期刊
FREE RADICAL RESEARCH
卷 44, 期 2, 页码 199-207出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715760903402898
关键词
Hydrogen peroxide; endothelial progenitor cells; exercise; reactive oxygen species
资金
- Heinrich-Heine-University Duesseldorf [9772272, 9772 345]
The number of circulating stem cells with endothelial progenitor capacity (EPCs) inversely correlates with the number of cardiovascular risk factors. In this study we sought to investigate the effects of vascular H2O2 on circulating EPC levels. In C57BL/6 mice 3 weeks of freely moving or forced physical activity or voluntary exercise failed to increase circulating EPCs defined as double positive for Flk-1 and CD34, CD133 or Sca-1. Likewise, neither insertion of additional genes encoding for catalase (cat(++)) or eNOS nor eNOS knock-out changed EPCs in resting mice. In striking contrast, inhibition of catalase by aminotriazole strongly reduced circulating EPCs in sedentary cat(++) and their transgen-negative littermates (cat(n)), while forced or voluntary exercise training of cat(++) mice significantly increased the number of circulating EPCs. The latter effect was completely inhibitable by aminotriazole. These data suggest that endogenous vascular H2O2 likely contributes to the impairment of important stem cell-induced vascular repair mechanisms in cardiovascular disease.
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