期刊
FREE RADICAL RESEARCH
卷 42, 期 5, 页码 514-522出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760802087431
关键词
vitamin C; arterial stiffness; oxidative stress; isoprostanes
Vitamin C is a potent antioxidant in vitro and has been reported to act as a vasodilator' possibly by increasing nitric oxide bioavailability. This study examined the antioxidant and vascular effects of a single large oral dose of vitamin C in 26 healthy human volunteers. Haemodynamic and oxidative DNA and lipid damage markers were measured for 8 h following an oral dose of 2 g vitamin C or placebo. Vitamin C had no effect on vasodilation (measured by augmentation index (mean change = 0.04%, 90% CI = - 2.20% to 2.28%) or forearm blood flow (-0.19%/min (-0.68, 0.30)), in comparison to placebo) or on several markers of oxidative stress including DNA base oxidation products in blood cells, 8-hydroxy-2'-deoxyguanosine (8O HdG) in urine (0.068 (- 0.009, 0.144)) or urinary or plasma total F-2-isoprostanes (-0.005 ng/ml (-0.021, 0.010), -0.153 ng/mg (-0.319, 0.014), respectively).
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