期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 132, 期 -, 页码 90-100出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2018.09.025
关键词
Cartilage; Chondrocytes; NF-kappa B; Osteoarthritis; Reactive oxygen species; Redox
Human cells have to deal with the constant production of reactive oxygen species (ROS). Although ROS overproduction might be harmful to cell biology, there are plenty of data showing that moderate levels of ROS control gene expression by maintaining redox signaling. Osteoarthritis (OA) is the most common joint disorder with a multi-factorial etiology including overproduction of ROS. ROS overproduction in OA modifies intracellular signaling, chondrocyte life cycle, metabolism of cartilage matrix and contributes to synovial inflammation and dysfunction of the subchondral bone. In arthritic tissues, the NF-kappa B signaling pathway can be activated by pro-inflammatory cytokines, mechanical stress, and extracellular matrix degradation products. This activation results in regulation of expression of many cytokines, inflammatory mediators, transcription factors, and several matrix-degrading enzymes. Overall, NF-kappa B signaling affects cartilage matrix remodeling, chondrocyte apoptosis, synovial inflammation, and has indirect stimulatory effects on downstream regulators of terminal chondrocyte differentiation. Interaction between redox signaling and NF-kappa B transcription factors seems to play a distinctive role in OA pathogenesis.
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