期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 69, 期 -, 页码 116-128出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2014.01.003
关键词
Unloading; Reloading; Muscle atrophy; Mitochondria; Lipoic acid; Acetyl-l-carnitine; Hydroxytyrosol; CoQ(10); Free radicals
资金
- Opening Foundation of the State Key Laboratory of Space Medicine Fundamentals and Application
- China Astronaut Research and Training Center [SMFA10K07]
- Merieux Research Starting Grant
- Fundamental Research Funds for the Central Universities
- Shaanxi Province Science and Technology Research and Development Program [2013K12-01-10]
- New Century Excellent Talents in University
- Tianjin Applied Basic and Frontier Tech Major Project [12JCZDJC34400]
- Tianjin higher Education Sci-tech Development Project [20112D05]
- National Natural Science Foundation of China [31070740]
- National Twelfth Five-Year Plan for Science & Technology Support Project
We previously found that mitochondrial dysfunction occurs in disuse-induced muscle atrophy. However, the mitochondrial remodeling that occurs during reloading, an effective approach for rescuing unloading-induced atrophy, remains to be investigated. In this study, using a rat model of 3-week hindlimb unloading plus 7-day reloading, we found that reloading protected mitochondria against dysfunction, including mitochondrial loss, abnormal mitochondrial morphology, inhibited biogenesis, and activation of mitochondria-associated apoptotic signaling. Interestingly, a combination of nutrients, including a-lipoic acid, acetyl-carnitine, hydroxytyrosol, and CoQ(10), which we designed to target mitochondria, was able to efficiently rescue muscle atrophy via a reloading-like action. It is suggested that reloading ameliorates skeletal muscle atrophy through the activation of mitochondrial biogenesis and the amelioration of oxidative stress. Nutrient administration acted similarly in unloaded rats. Here, the study of mitochondrial remodeling in rats during unloading and reloading provides a more detailed picture of the pathology of muscle atrophy. (C) 2014 Elsevier Inc. All rights reserved.
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