期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 71, 期 -, 页码 368-378出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2014.03.038
关键词
Aging; Life span; Longevity; Age-related disease; Mouse models; Free radicals
资金
- Geriatric Research, Education and Clinical Center of the South Texas Veterans Health Care Systems
- San Antonio Nathan Shock Center [NIA 5P30 AG013319-19]
- San Antonio Area Foundation
Significant advances in maintaining health;throughout life can be made through a clear understanding of the fundamental mechanisms that regulate aging. The Oxidative Stress Theory of Aging (OSTA) is probably the most well studied mechanistic theory of aging and suggests that the rate of aging is controlled by accumulation of oxidative damage. To directly test the OSTA, aging has been measured in several lines of mice with genetic alterations in the expression of enzymatic antioxidants. Under its strictest interpretation, these studies do not support the OSTA, as modulation of antioxidant expression does not generally affect mouse life span. However, the incidence of many age-related diseases and pathologies is altered in these models, suggesting that oxidative stress does significantly influence some aspects of the aging process. Further, oxidative stress may affect aging in disparate patterns among tissues or under various environmental conditions. In this review, we summarize the current literature regarding aging in antioxidant mutant mice and offer several interpretations of their support of the OSTA. Published by Elsevier Inc.
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