期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 75, 期 -, 页码 222-229出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2014.07.034
关键词
Resveratrol; Periodontitis; Sirt1; AMPK; Nrf2; Cytokines; Oxidative stress; Free radicals
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [24593155]
- Yamada research grant
- Grants-in-Aid for Scientific Research [24593155] Funding Source: KAKEN
Oxidative stress is a key factor regulating the systemic pathophysiological effects associated with periodontitis. Resveratrol is a phytochemical with antioxidant and anti-inflammatory properties that can reduce oxidative stress and inflammation. We hypothesized that resveratrol may prevent the progression of periodontitis and reduce systemic oxidative stress through the activation of the sirtuin 1 (Sirt1)/AMP-activated protein kinase (AMPK) and the nuclear factor E2-related factor 2 (Nrf2)/antioxidant defense pathways. Three groups of male Wistar rats (periodontitis treated with melinjo resveratrol, periodontitis without resveratrol, and control rats with no periodontitis or resveratrol treatment) were examined. A ligature was placed around the maxillary molars for 3 weeks to induce periodontitis, and the rats were then given drinking water with or without melinjo resveratrol. In rats with periodontitis, ligature placement ihduced alveolar bone resorption, quantified using three-dimensional images taken by micro-CT, and increased proinflammatory cytokine levels in gingival tissue. Melinjo resveratrol intake relieved alveolar bone resorption and activated the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in inflamed gingival tissues. Further, melinjo resveratrol improved the systemic levels of 8-hydroxydeoxyguanosine, dityrosine, nitric oxide metabolism, nitrotyrosine, and proinflammatory cytokines. We conclude that oral administration of melinjo resveratrol may prevent the progression of ligature-induced periodontitis and improve systemic oxidative and nitrosative stress. (C) 2014 Elsevier Inc. All rights reserved.
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