期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 64, 期 -, 页码 61-68出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2013.05.034
关键词
Endothelium; Shear stress; MiR; KLF2; Oxidative stress; Inflammation; Free radicals
资金
- National Institutes of Health [HL106579, HL108735, HL89940]
Endothelial functions are highly regulated by imposed shear stress in vivo. The characteristics of shear stress determine mechanotransduction events that regulate phenotypic outcomes including redox and inflammatory states. Recent data indicate that microRNAs (miRs) in vascular endothelial cells play an essential role in shear stress-regulated endothelial responses. More specifically, atheroprotective pulsatile flow (PS) induces miRs that inhibit mediators of oxidative stress and inflammation while promoting those involved in maintaining vascular homeostasis. Conversely, oscillatory flow (OS) elicits the opposing networks. This is exemplified by the PS-responsive transcription factor Kruppel-like factor 2 (KLF2), which regulates miR expression but is also regulated by OS-sensitive miRs to ultimately regulate the oxidative and inflammatory state of the endothelium. In this review, we outline important findings demonstrating the multifaceted roles of shear stress-regulated miRs in endothelial redox and inflammatory balance. Furthermore, we discuss the use of algorithms in deciphering signaling networks differentially regulated by PS and OS. (c) 2013 Elsevier Inc. All rights reserved.
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