期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 62, 期 -, 页码 65-75出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2013.01.032
关键词
Manganese; Reactive oxygen species; Mitochondrial dysfunction; Manganism; DA autoxidation; Free radicals
资金
- National Institutes of Environmental Health Sciences [R01-10563, T32-007028, P30 000267]
Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body. (C) 2013 Elsevier Inc. All rights reserved.
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