期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 62, 期 -, 页码 13-25出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2013.05.001
关键词
Glutathione; Glutathione S-transferase; Parkinson's disease; Oxidative Stress; Substantia nigra
资金
- NINDS NIH HHS [R01 NS070825] Funding Source: Medline
It has been established that oxidative stress, defined as the condition in which the sum of free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the pathogenesis of Parkinson disease. Glutathione is a ubiquitous thiol tripeptide that acts alone or in concert with enzymes within cells to reduce superoxide radicals, hydroxyl radicals, and peroxynitrites. In this review, we examine the synthesis, metabolism, and functional interactions of glutathione and discuss how these relate to the protection of dopaminergic neurons from oxidative damage and its therapeutic potential in Parkinson disease. (C) 2013 Elsevier Inc. All rights reserved.
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