期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 52, 期 3, 页码 556-592出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2011.11.002
关键词
Vasomotor dysfunction; Leukocyte-endothelial cell adhesion; Angiogenesis; Vascular permeability; Coagulation; Thrombosis; Free radicals
资金
- National Heart, Lung, and Blood Institute [R01-HL26441]
- National Institutes of Diabetes and Digestive and Kidney Diseases [P01-DK43785]
Inflammation is a complex and potentially life-threatening condition that involves the participation of a variety of chemical mediators, signaling pathways, and cell types. The microcirculation, which is critical for the initiation and perpetuation of an inflammatory response, exhibits several characteristic functional and structural changes in response to inflammation. These include vasomotor dysfunction (impaired vessel dilation and constriction), the adhesion and transendothelial migration of leukocytes, endothelial barrier dysfunction (increased vascular permeability), blood vessel proliferation (angiogenesis), and enhanced thrombus formation. These diverse responses of the microvasculature largely reflect the endothelial cell dysfunction that accompanies inflammation and the central role of these cells in modulating processes as varied as blood flow regulation, angiogenesis, and thrombogenesis. The importance of endothelial cells in inflammation-induced vascular dysfunction is also predicated on the ability of these cells to produce and respond to reactive oxygen and nitrogen species. Inflammation seems to upset the balance between nitric oxide and superoxide within (and surrounding) endothelial cells, which is necessary for normal vessel function. This review is focused on defining the molecular targets in the vessel wall that interact with reactive oxygen species and nitric oxide to produce the characteristic functional and structural changes that occur in response to inflammation. This analysis of the literature is consistent with the view that reactive oxygen and nitrogen species contribute significantly to the diverse vascular responses in inflammation and supports efforts that are directed at targeting these highly reactive species to maintain normal vascular health in pathological conditions that are associated with acute or chronic inflammation. (C) 2011 Elsevier Inc. All rights reserved.
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