期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 52, 期 11-12, 页码 2201-2208出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2012.03.008
关键词
Mitochondria; Compartments; Antioxidants; Mitochondrially-targeted probes; Mitochondrially-targeted antioxidants
Knowledge of location and intracellular subcompartmentalization is essential for the understanding of redox processes, because oxidants, owing to their reactive nature, must be generated close to the molecules modified in both signaling and damaging processes. Here we discuss known redox characteristics of various mitochondrial microenvironments. Points covered are the locations of mitochondrial oxidant generation, characteristics of antioxidant systems in various mitochondrial compartments, and diffusion characteristics of oxidants in mitochondria. We also review techniques used to measure redox state in mitochondrial subcompartments, antioxidants targeted to mitochondrial subcompartments, and methodological concerns that must be addressed when using these tools. (C) 2012 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据