期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 52, 期 7, 页码 1188-1200出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2011.12.027
关键词
Hydroxyl radical; Singlet oxygen; Superoxide; Bacteriochlorins; Phototoxicity; Photochemical mechanism; Photodynamic therapy; Free radicals; Ascorbate
资金
- ERA Chemistry (The National Centre for Research and Development, FCT-FEDER) [60303, 0002/2008]
- European Regional Development Fund in the framework of the Polish Innovation Economy Operational Program [POIG.02.01.00-12-023/08]
Sulfonamides of halogenated bacteriochlorins bearing Cl or F substituents in the ortho positions of the phenyl rings have adequate properties for photodynamic therapy, including strong absorption in the near-infrared (lambda(max) approximate to 750 nm, epsilon approximate to 10(5) m(-1) cm(-1)) controlled photodecomposition, large cellular uptake, intracellular localization in the endoplasmic reticulum, low cytotoxicity, and high phototoxicity against A549 and S91 cells. The roles of type I and type II photochemical processes are assessed by singlet oxygen luminescence and intracellular hydroxyl radical detection. Phototoxicity of halogenated sulfonamide bacteriochlorins does not correlate with singlet oxygen quantum yields and must be mediated both by electron transfer (superoxide ion, hydroxyl radicals) and by energy transfer (singlet oxygen). The photodynamic efficacy is enhanced when cellular death is induced by both singlet oxygen and hydroxyl radicals. (C) 2012 Elsevier Inc. All rights reserved.
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