期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 52, 期 2, 页码 257-265出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2011.10.447
关键词
Thioredoxin; Redox; Cancer; Selenocysteine
资金
- National Natural Science Found of China [21002047, 21071069]
- Ministry of Education of China [20100211110027]
- 111 Project
- Lanzhou University [Izujbky-2009-73]
Mammalian thioredoxin reductases (TrxRs) are a family of NADPH-dependent flavoproteins with a penultimate selenocysteine residue at the carboxy-terminus. Besides their native substrate thioredoxins (Trx), the enzymes show a broad substrate specificity, at least partially, because of the C-terminal redox-active site that is easily accessible in the reduced form. TrxRs are ubiquitous in all kinds of cells and have a critical role in regulating intracellular redox signaling. In recent years, a wealth of evidence has revealed that overactivation/dysfunction of TrxRs is closely related to various diseases, especially in tumor development, and thus the past decades have witnessed an expanding interest in finding TrxRs inhibitors, which might be promising agents for cancer chemotherapy. Herein we reviewed the small molecule inhibitors of mammalian TrxRs, with an emphasis on those that have potential anticancer activity. This review includes the nonpatent references up to 2010 that deal with mammalian TrxR inhibitors. (C) 2011 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据