期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 50, 期 9, 页码 1053-1064出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2011.02.004
关键词
Aging; AIF; Antioxidants; Carbonyls; DPH; Electron transport chain; Free radicals; Lipid peroxidation; Membrane fluidity; Sunflower oil; Ubiquinone; Virgin olive oil
资金
- Spanish Ministry of Education and Science [1FD97-0457-c02-01, BFU2009-11879/BFI, AGL2006-12433, AGL2008-01057]
- Spanish Ministry of Health [RD06/0013/0012, PI04/0355, PI05/2214]
- Autonomous Government of Andalusia [AGR832]
- Autonomous Government of Catalonia [2009SGR735]
Mitochondria-related oxidative damage is a primary event in aging and age-related neurodegenerative disorders. Some dietary treatments, such as antioxidant supplementation or the enrichment of mitochondrial membranes with less oxidizable fatty acids, reduce lipid peroxidation and lengthen life span in rodents. This study compares life-long feeding on monounsaturated fatty acids (MUFAs), such as virgin olive oil, and n-6 polyunsaturated fatty acids, such as sunflower oil, with or without coenzyme Q(10) supplementation, with respect to age-related molecular changes in rat brain mitochondria. The MUFA diet led to diminished age-related phenotypic changes, with lipoxidation-derived protein markers being higher among the older animals, whereas protein carbonyl compounds were lower. It is noteworthy that the MUFA diet prevented the age-related increase in levels of mitochondrial DNA deletions in the brain mitochondria from aged animals. The findings of this study suggest that age-related oxidative stress is related, at the mitochondrial level, to other age-related features such as mitochondrial electron transport and mtDNA alterations, and it can be modulated by selecting an appropriate dietary fat type and/or by suitable supplementation with low levels of the antioxidant/electron carrier molecule coenzyme Q. (C) 2011 Elsevier Inc. All rights reserved.
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