期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 46, 期 5, 页码 586-592出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.11.013
关键词
Aspirin; Hydrogen sulfide; Dithiolethione; Thromboxane; Glutathione; Heme oxygenase-1; Free radicals
The pharmacological profile of a new, safe, and effective hydrogen sulfide (H2S)-releasing derivative of aspirin (ACS14) is described. We report the synthesis of ACS14, and of its deacetylated metabolite (ACS21), the preliminary pharmacokinetics, and its in vivo metabolism, with the H2S plasma levels after intravenous administration in the rat. ACS14 maintains the thromboxane-suppressing activity of the parent compound, but seems to spare the gastric mucosa, by affecting redox imbalance through increased H2S/glutathione formation, heme oxygenase-1 promoter activity, and isoprostane suppression. (C) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据