期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 46, 期 5, 页码 573-578出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.11.005
关键词
White wine; Red wine; Resveratrol; Tyrosol; Hydroxytyrosol; PBEF; SirT1; FoxO1; Longevity; Cardioprotection
资金
- NIH [HL 22559, HL33889, HL34360]
Resveratrol increases longevity through SirT1, which is activated with NAD(+) supplied by an anti-aging enzyme PEER SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine>resveratrol>tyrosol>hydroxytyrosol>red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol>red wine>hydroxytyrosol>white wine>tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据