期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 47, 期 4, 页码 333-343出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2009.05.004
关键词
Mitochondria; Oxidative stress; Free radicals; Respiration; Uncoupling; Electron transport chain; Energy metabolism
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Instituto Nacional de Processos Redox em Biomedicina-Redoxoma
- Instituto Nacional de Obesidade e Diabetes
- Pro-Reitoria de Pesquisa
- USP
Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the majority of cell types. Here we review the sources and metabolism of ROS in this organelle, including the conditions that regulate the production of these species, such as mild uncoupling, oxygen tension, respiratory inhibition, Ca2+ and K+ transport, and mitochondrial content and morphology. We discuss substrate-, tissue-, and organism-specific characteristics of mitochondrial oxidant generation. Several aspects of the physiological and pathological roles of mitochondrial ROS production are also addressed. (C) 2009 Elsevier Inc. All rights reserved.
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