期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 47, 期 8, 页码 1108-1119出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2009.07.024
关键词
GTP cyclohydrolase I; Dihydrobiopterin; Neopterin; Endothelial nitric oxide synthase
资金
- National Institutes of Health
- National Heart Blood and Lung Institute [HL067244]
- National Institute of Neurological Disorders and Stroke [NS054017]
(6R)-5,6,7,8-Tetrahydrobiopterin (BH4) is an endogenously produced pterin that is found widely distributed in mammalian tissues. BH4 works as a cofactor of aromatic amino acid hydroxylases and nitric oxide synthases. In the vasculature a deficit of BH4 is implicated in the mechanisms of several diseases including atherosclerosis, hypertension, diabetic vascular disease, and vascular complications from cigarette smoking and environmental pollution. These ill-effects are connected to the ability of BH4 to regulate reactive oxygen species levels in the endothelium. The possibility of using BH4 as a therapeutical agent in cardiovascular medicine is becoming more compelling and many biochemical and physiological aspects involved in this application are currently under investigation. This review summarizes our current understanding of BH4 reactivity and some aspects of cellular production and regulation. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据