期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 46, 期 3, 页码 387-396出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.10.036
关键词
Mitochondria; Reactive oxygen species; Glycolysis; Lymphoma; p53; c-myc; Free radicals
资金
- Spanish Ministry of Health and Consumer Affairs
- Pro-CNIC Foundation
- National Institutes of Health [AG18679]
- Ellison Medical Foundation
- EMBO
- Spanish Ministry of Education
- Ministry of Health [PIFIS07/1023, 06/0701]
- Fundacion Mutua Madrilena
Lymphomas adapt to their environment by undergoing a complex series of biochemical changes that are Currently not well understood. To better define these changes, we examined the gene expression and gene ontology profiles of thymic lymphomas from a Commonly used model of carcinogenesis, the p53(-/-) mouse. These tumors show a highly Significant upregulation of mitochondrial biogenesis, mitochondrial protein translation, mtDNA copy number, reactive oxygen species, antioxidant defenses, proton transport, ATP synthesis, hypoxia response, and glycolysis, indicating a fundamental change in the bioenergetic profile of the transformed T cell. Our results suggest that T cell tumorigenesis involves a simultaneous upregulation of mitochondrial biogenesis, mitochondrial respiration, and glycolytic activity. These processes would allow cells to adapt to the stressful tumor environment by facilitating energy production and thereby promote tumor growth. Understanding these adaptations is likely to result in improved therapeutic strategies for this tumor type. (C) 2008 Elsevier Inc. All rights reserved.
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