期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 45, 期 3, 页码 219-230出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.04.022
关键词
Alzheimer's disease; mild cognitive impairement; oxidative damage; anti-oxidants
资金
- Intramural NIH HHS [Z01 AG000258] Funding Source: Medline
- NIA NIH HHS [P50 AG005136-25, T32 AG000258, T32 AG000258-10, AG024010, AG028383, P01 AG005119, P30 AG028383-02, P30 AG008017, R01 AG024011, R01 AG024010-05, AG24011, AG000258, P50 AG005136, P30 AG008017-10S2, P01 AG005119-19, P30 AG028383, R01 AG024011-05, P50 AG005136-259003, R01 AG024010, AG08017, AG005119, AG05136] Funding Source: Medline
Advances in our understanding of the etiologies and pathogenesis of Alzheimer's disease (AD) highlight a role for free radical-mediated injury to brain regions from early stages of this illness. Here we will review the evidence from transgenic mouse models of AD, autopsy samples, and human biofluids obtained during life paying particular attention to the stage of disease. In addition, we Will review the epidemiologic literature that addresses the potential of anti-oxidants to prevent incident dementia from AD, and the clinical trial literature that addresses anti-oxidant preventative or therapeutic strategies for different stage of AD. Future efforts in preclinical models and ultimately clinical trials are needed to define optimally effective agents and combinations, doses, and timing to suppress safely this facet of AD. (c) 2008 Elsevier Inc. All rights reserved.
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