期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 45, 期 2, 页码 119-123出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.04.013
关键词
oxidized phospholipids; Ox-PAPC; Kodia PC; POVPC; PEIPC; signaling
资金
- NHLBI NIH HHS [P01 HL030568, R01 HL064731, P01 HL30568, P01 HL030568-230006, R01 HL 064731, R01 HL064731-08] Funding Source: Medline
Oxidized phospholipids accumulate in atherosclerotic lesions, on lipoproteins, in other states of chronic inflammation, on apoptotic cells, necrotic cells and cells exposed to oxidative stress. These lipids regulate the transcription of over 1000 gene, regulating many endothelial functions, by activating several different cell surface receptors and multiple signaling pathways. These lipids also have important effects not involving transcription that regulate cell junctions and leukocyte binding. Thus these lipids are potent regulators of endothelial cell function with broad effects comparable in extent but differing from those of cytokines. (C) 2008 Elsevier Inc. All rights reserved.
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