期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 44, 期 10, 页码 1787-1794出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.03.005
关键词
oxidation; nitration; HNE; 3NT; posttranslational modification; Parkinson's disease
资金
- NINDS NIH HHS [RL1 NS062415, RL1 NS062415-01] Funding Source: Medline
Parkinson's disease (PD) is a complex neurodegenerative syndrome likely involving contributions from various factors in individuals including genetic susceptibility, exposure to environmental toxins, and the aging process itself. Increased oxidative stress appears to be a common causative aspect involved in the preferential loss of dopaminergic neurons in a region of the brain prominently affected by the disorder, the substantia nigra (SN). Loss of dopaminergic SN neurons is responsible for the classic clinical motor symptoms associated with PD. Several oxidative and nitrative posttranslational modifications (PTMs) have been identified on proteins pertinent to PD that may affect this or other aspects of disease progression. In this review, we discuss several examples of such PTMs to illustrate their potential consequences in terms of initiation or progression of PD neuropathophysiology. (C) 2008 Elsevier Inc. All rights reserved.
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