Preparation and characterization of biologically active novel copper ion-pairs of nonsteroidal anti-inflammatory drugs (NSAIDs)

The present work is concerned with preparation, separation and structure elucidation of solid ion-pairs of nonsteroidal anti-inflammatory drugs in reaction to copper(II) ion. The prepared solid ion-pairs were investigated by different analytical techniques, such as FT-IR, mass and thermogravimetric and differential thermal analyses, in addition to elemental analysis. The general formulae of the prepared ion-pairs were determined. Moreover, the formulae of prepared ion-pairs were proposed and structurally identified. The biological activities of the separated solid ion-pairs toward some kinds of insect species in flour mills in comparison with their drugs were studied, and they were found to be biologically active more than their parent drugs. The present work involved the preparation, separation and structures elucidation of Cu(II) ion-pairs of nonsteroidal anti-inflammatory drugs (NSAIDs). Their proposed structures (a-d) are given.