期刊
FORENSIC SCIENCE INTERNATIONAL
卷 239, 期 -, 页码 50-56出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.forsciint.2014.03.018
关键词
Codeine; Pharmacogenetics; Drug interactions; CYP2D6; ABCB1; Post-mortem
资金
- Office of the Chief Coroner of Ontario
The objective of this study was to assess the relationship between genetic polymorphisms and drug interactions on codeine and morphine concentrations in codeine-related deaths (CRD). All CRD in Ontario, Canada between 2006 and 2008 were identified. Post-mortem blood was analyzed for 22 polymorphisms in 5 genes involved in codeine metabolism and response. Sixty-eight CRD were included in this study. The morphine-to-codeine ratio was significantly correlated with the presence of a CYP2D6 inhibitor at varying potencies (p = 0.0011). The presence of other central nervous system (CNS) depressants (i.e. benzodiazepines, hypnotics, and/or alcohol) was significantly associated with lower codeine concentration as compared to CRD in which other CNS depressants were not detected (p = 0.0002). Individuals who carried the ABCB1 1236T variant had significantly lower morphine concentrations (p = 0.004). In this population of individuals whose cause of death was related to codeine, drug interactions and genetic polymorphisms were significantly associated with post-mortem codeine and morphine concentrations. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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