期刊
FORENSIC SCIENCE INTERNATIONAL
卷 179, 期 2-3, 页码 111-122出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.forsciint.2008.04.024
关键词
cocaine; static headspace-gas chromatography; residual solvents; drug intelligence; inter-sample correlation; fractional factorial design; database
A method for determination of residual solvents in illicit hydrochloride cocaine samples using static headspace-gas chromatography (HS-GC) associated with a storage computerized procedure is described for the profiling and comparison of seizures. The system involves a gas chromatographic separation of 18 occluded solvents followed by fully automatic data analysis and transfer to a PHP/MySQL database. First, a fractional factorial design was used to evaluate the main effects of some critical method parameters (salt choice, vial agitation intensity, oven temperature, pressurization and loop equilibration) on the results with a minimum of experiments. The method was then validated for tactical intelligence purposes (batch comparison) via several studies: selection of solvents and mathematical comparison tool, reproducibility and cutting influence studies. The decision threshold to determine the similarity of two samples was set and false positives and negatives evaluated. Finally, application of the method to distinguish geographical origins is discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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