期刊
FOOD RESEARCH INTERNATIONAL
卷 63, 期 -, 页码 233-238出版社
ELSEVIER
DOI: 10.1016/j.foodres.2014.01.018
关键词
Dietary polyphenol; Phenolic metabolites; Human compliance; Biomarkers
资金
- ETHERPATHS project (European Commission) [FP7-KBBE-222639]
- Diabete Ricerca
Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet. (C) 2014 Elsevier Ltd. All rights reserved.
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