期刊
FOOD RESEARCH INTERNATIONAL
卷 64, 期 -, 页码 839-848出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.foodres.2014.08.012
关键词
Obesity; Cafeteria diet; Post-cafeteria model; Weight loss; Adipose tissue
资金
- Spanish Government (Ministerio de Educacion y Ciencia) [EPIMILK-AGL2012-33692]
- EU [BIOCLAIMS-FP7-244995, FOOD-CT-2004-506360 NUGO]
- Direccio General d'Universitats, Recerca i Transferencia del Coneixement of Regional Government (CAIB)
- FEDER funds (EU)
- University of the Balearic Islands
- Spanish Government
- Group of Excellence of CAIB
The increased intake of fat-rich foods is one of the causes of the increasing incidence of obesity. However, there are controversial data on the reversibility of diet-induced obesity and its metabolic complications when adopting a control energy-balanced diet. Our aim was to evaluate the ability to reset not only body weight but also metabolic disorders caused by a highly palatable high fat diet, cafeteria diet, administered to adult rats, when replaced by a control diet (post-cafeteria model). Four-months of cafeteria diet-feeding produced important metabolic alterations in comparison to a commercial purified high fat diet: a rapid, drastic increase in body weight, adiposity and related complications such as insulin resistance, decreased glucose tolerance and development of hepatic steatosis. At gene level, decreased lipogenic and increased lipolytic gene expression in key energy homeostatic tissues as a physiological adaptation to increased fat intake was observed. In addition, fasting response of serum parameters and of key genes in lipid metabolism was impaired in cafeteria-fed animals. Contrary to what we have previously described if cafeteria diet is administered early in life, when administered to adult animals, its replacement with a balanced diet is able to restore body weight. Cafeteria diet withdrawal also allows recovery from metabolic damage, gene expression regulation and fasting response, the degree of which is dependent on the time of exposure to the cafeteria diet. In conclusion, adherence to an ad libitum intake of a balanced standard diet can enable the recovery of healthy status in animals which were previously exposed to an unhealthy cafeteria diet in adult age. (C) 2014 Elsevier Ltd. All rights reserved.
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