Chemistry and medicinal properties of the Bakul (Mimusops elengi Linn): A review

India is one of the world's biodiversity hotspots and reports confirm that a great variety of fruiting trees are indigenous to this region of the world. Mimusops elengi Linn (family Sapotaceae) commonly known as Bakul is one such tree native to the Western Ghat region of the peninsular India. However, today this tree is also found growing in other parts of the tropical and subtropical regions of the world. The tree is of religious importance to the Hindus and finds mention in various mythological texts. The stem, barks, leaves and fruits are used in various Ayurvedic and folk medications to treat various ailments. In the prehistoric days the ripe fruits were an important source of diet but today no one knows of its dietary use as it is seldom used. Studies suggest the tree contains medicinally-important chemicals, particularly the triterpenes and alkaloids. Preclinical studies in the past five years have shown that the extracts prepared from Bakul possess antibacterial, antifungal. anticariogenic, free radical scavenging, antihyperglycemic, antineoplastic, gastroprotective, antinociceptive and diuretic effects, thus lending pharmacological support to the tree's ethnomedicinal uses in Ayurveda. In this review for the first time attempt is made at addressing the chemical constituents, medicinal uses and validated pharmacological observations of Bakul. (C) 2011 Elsevier Ltd. All rights reserved.