Electrodepositing of copper nanowires on layered double hydroxide film modified glassy carbon electrode for the determination of doxorubicin

A novel doxorubicin sensor has been developed by electrodepositing of copper nanowires on Mg2Al layered double hydroxides modified glassy carbon. The morphology of synthesized Cu nanowires/Mg-2 Al layered double hydroxides was characterized by field-emission scanning electron microscopy and energy dispersive X-ray spectroscopy. The modified electrode has a catalytic effect on the oxidation current of doxorubicin. The oxidation mechanism was studied using cyclic voltammetry, chronoamperometry and electrochemical impedance spectroscopy. Under optimized chemical and instrumental condition, the differential pulse voltammetry response of modified electrode toward doxorubicin shows a linear concentration range of 10.0-2110.0 nmol/L with the detection limit of 0.02 nmol/L at the signal to noise of 3. Satisfactory results have been achieved for the determination of doxorubicin with a doxorubicin injection solution and biological samples. (C) 2015 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.