期刊
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
卷 80, 期 7, 页码 839-852出版社
SERBIAN CHEMICAL SOC
DOI: 10.2298/JSC150116013B
关键词
azepines; thiepines; heterocycles; palladium; antibacterials; antifungal
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [172008]
- Serbian Academy of Sciences and Arts
A series of new pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The pyridobenzazepine derivatives showed better antibacterial and antifungal activity than the corresponding dipyridoazepine analogue. Among the synthesized azepines, derivative 8 displayed potent activity against the tested bacteria (MIC ranged 39-78 mu g mL(-1)), while azepine 12 showed promising antifungal activity (MIC ranged 156-313 mu g mL(-1)). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.
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