期刊
FOOD CHEMISTRY
卷 160, 期 -, 页码 148-156出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2014.03.052
关键词
Lipid homeostasis; Free amino-acid composition; Carnosine/anserine; Chicken-liver hydrolysates; Bile-acid binding ability; Pancreatic lipase inhibitory activity; Antioxidant capacity
资金
- National Science Council, Taiwan (R.O.C.) [NSC 102-2313-B-002039-MY3]
The contents of free hydrophobic amino acids, taurine and carnosine/anserine were elevated after hydrolyzing chicken livers by pepsin and compared to dried chicken livers. Chicken-liver-hydrolysates (CLHs) exhibited in vitro inhibitory lipase activity and bile-acid binding ability (p < 0.05). Forty-eight male hamsters were assigned randomly to the following groups: (1) chow diet; (2) high-fat diet (HFD); (3) HFD and 100 mg CLH/kg BW; (4) HFD and 200 mg CLH/kg BW; (5) HFD and 400 mg CLH/kg BW; (6) HFD and 200 mg carnosine/kg BW. CLHs alleviated (p < 0.05) serum oxidative stress and improved (p < 0.05) the serum lipid profile in the high-fat dietary groups; meanwhile, improved (p < 0.05) antioxidant abilities and decreased (p < 0.05) lipid accumulation, oxidative stress and TNF-alpha/IL-1 beta levels in the livers. These benefits might result from regulations of lipid homeostasis and increased faecal bile-acid outputs (p < 0.05). Hence, lipid-homeostasis and antioxidant abilities of CLHs in the high-fat dietary habit were demonstrated and were similar to pure carnosine. (C) 2014 Elsevier Ltd. All rights reserved.
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