期刊
FOOD CHEMISTRY
卷 148, 期 -, 页码 453-460出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.08.002
关键词
Curcumin; Urinary tract infection; Quorum sensing; Biofilm; Antibiotic resistance
资金
- Department of Biotechnology, Government of India [BT/BI/25/001/2006]
- UGC Research fellowships in Sciences for Meritorious Students [F.4-3/2006(BSR)/11-61/2008(BSR)]
Urinary tract infection is caused primarily by the quorum sensing (QS)-dependent biofilm forming ability of uropathogens. In the present investigation, an anti-quorum sensing (anti-QS) agent curcumin from Curcuma longa (turmeric) was shown to inhibit the biofilm formation of uropathogens, such as Escherichia coli, Pseudomonas aeruginosa PAO1, Proteus mirabilis and Serratia marcescens, possibly by interfering with their QS systems. The antibiofilm potential of curcumin on uropathogens as well as its efficacy in disturbing the mature biofilms was examined under light microscope and confocal laser scanning microscope. The treatment with curcumin was also found to attenuate the QS-dependent factors, such as exopolysaccharide production, alginate production, swimming and swarming motility of uropathogens. Furthermore, it was documented that curcumin enhanced the susceptibility of a marker strain and uropathogens to conventional antibiotics. (C) 2012 Elsevier Ltd. All rights reserved.
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