Effect of spinach aqueous extract on wound healing in experimental model diabetic rats with streptozotocin

BACKGROUNDChronic ulcer is still a serious issue for diabetic patients. Diabetes is a prevalent cause of ulcer regeneration delay and (or) disruption. Since Spinacia oleracea extract contains compounds with anti-oxidative and anti-inflammatory effects, this may be effective in accelerating the healing process of ulcers, especially diabetic ulcers. Hence, this study examined the effect of Spinacia oleracea aqueous extract on ulcer regeneration in an experimental animal model. RESULTSMacroscopic examination of the wounds of the control group and spinach aqueous extract group between 7 and 21 days compared with diabetic group, significant changes were observed (P < 0.05). On microscopic examination, epithelial tissue formation, formation of granulation tissue and new blood vessels in the spinach aqueous extract group and non-diabetic group compared to the diabetic group showed significant improvements (P < 0.05). Also, significant differences in vascular endothelial growth factor were observed between groups on days 3 and 7 (P < 0.05). CONCLUSIONThe Spinacia oleracea aqueous extract can be effective in regenerating diabetic ulcers. It affects the speed and structure of the ulcer. (c) 2015 Society of Chemical Industry