期刊
FOOD CHEMISTRY
卷 141, 期 2, 页码 900-906出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2013.03.097
关键词
Luteolin; Cyclodextrin; Inclusion complex; Characterisation; Docking
资金
- Australian Federal Government
- National Natural Science Foundation of China [31101232, 21166024]
The formation of supramolecular inclusion complexes between luteolin and five cyclodextrins namely beta-cyclodextrin (beta-CD), methyl-beta-cyclodextrin (M-beta-CD), hydroxyethyl-beta-cyclodextrin (HE-beta-CD), hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and glucosyl-beta-cyclodextrin (G-beta-CD) was investigated. Results from phase-solubility studies showed that luteolin formed 1:1 stoichiometric inclusion complexes with these cyclodextrins with the G-beta-CD complex displaying the greatest stability constant. The supramolecular structure of the luteolin/G-beta-CD complex was investigated by ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). Results showed clearly the formation of a supramolecular complex in which the guest molecule, luteolin, was entrapped inside the cavity of the host, G-beta-CD. The close association between luteolin and G-beta-CD resulted in changes in some of the characteristic spectral, phase transitional and morphological properties of luteolin. Furthermore, molecular docking study showed that the complex was formed with the B ring of luteolin inserted into the cavity of G-beta-CD. (C) 2013 Elsevier Ltd. All rights reserved.
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