期刊
FOOD CHEMISTRY
卷 141, 期 1, 页码 482-487出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2013.03.046
关键词
Mulberry; Anthocyanin; High-fat diet; Body weight gain; Obesity
资金
- National Key Technology R&D Program of China [2012BAD33B08]
- National Natural Science Foundation of China [31000775]
- Zhejiang Innovation Program for Graduates [YK2011008]
- Special Fund for Agro-scientific Research in the Public Interest [200903044]
We present our experiment about adding anthocyanins to the daily food of mice. Three kinds of anthocyanins (cyanidin-3-glucoside, cyanidin-3-rutinoside and pelargonidin-3-glucoside) purified from Chinese mulberry (Mows australis Poir) were evaluated for suppressing body weight gain of the male C57BL/6 mice fed with high-fat diet (HFD). The results from a 12-week experiment show that consumption of purified mulberry anthocyanins (MACN) of 40 or 200 mg/kg can significantly inhibit body weight gain, reduce the resistance to insulin, lower the size of adipocytes, attenuate lipid accumulation and decrease the leptin secretion. Thus, dietary supplementation with MACN can protect against body weight gain of the diet-induced obese mice. (C) 2013 Elsevier Ltd. All rights reserved.
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