期刊
FOOD CHEMISTRY
卷 139, 期 1-4, 页码 87-92出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2013.01.108
关键词
Melicope glabra; beta-Carotene bleaching; DPPH; Total phenolic content (TPC); Glabranin; Umbelliferone; Scopoletin; Sesamin; Pyranocoumarin
资金
- Malaysian government
The ethyl acetate and methanol bark extracts of Melicope glabra were evaluated for their antioxidant capacities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and beta-carotene bleaching/linoleic acid system. Both extracts exhibited strong inhibition against the DPPH radical (IC50 values of 24.81 and 13.01 mu g ml(-1), respectively) and strong antioxidant activity in beta-carotene bleaching assay. Both samples were found to have high phenolic content with values of 39 and 44 mg GAE/g as indicated by Follin-Ciocalteau's reagent. Antioxidant TLC assay-guided isolation on the methanol extract led to the isolation of a new pyranocoumarin, glabranin (1), umbelliferone (2), scopoletin (3) and sesamin (4), and their structures were determined by spectroscopy. Compounds (1-3) showed significant activities on DPPH free radical with the IC50 of 240.20, 810.02 and 413.19 mu g ml(-1), respectively. However, in beta-carotene bleaching assay, sesamin (4) showed higher inhibitory activity (1 mg ml(-1), 95%) than glabranin (1) (1 mg ml(-1), 74%), whilst umbelliferone (2) and scopoletin (3) were slightly pro-oxidant. (c) 2013 Elsevier Ltd. All rights reserved.
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