期刊
FOOD CHEMISTRY
卷 136, 期 1, 页码 170-177出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.07.124
关键词
Ginger; Zingerone; Inflammatory bowel diseases; Nuclear factor-kappa B; Interleukin-1 beta
资金
- National Science Council
- Committee on Chinese Medicine and Pharmacy at Department of Health [CCMP100-RD-048, CCMP101-RD-103]
- China Medical University [CMU100-S-16, CMU100-S-34, CMU100-TS-14]
Ginger is a commonly used spice with anti-inflammatory potential. Colitis is the common pathological lesion of inflammatory bowel diseases. In this study, we investigated the therapeutic effects of ginger and its component zingerone in mice with 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. Ginger and zingerone ameliorated TNBS-induced colonic injury in a dose-dependent manner. Pathway analysis of ginger- and zingerone-regulated gene expression profiles showed that ginger and zingerone significantly regulated cytokine-related pathways. Network analysis showed that nuclear factor-kappa B (NF-kappa B) and interleukin-1 beta (IL-1 beta) were key molecules involved in the expression of ginger- and zingerone-affected genes. Ex vivo imaging and immunohistochemical staining further verified that ginger and zingerone suppressed TNBS-induced NF-kappa B activation and IL-1 beta protein level in the colon. In conclusion, ginger improved TNBS-induced colitis via modulation of NF-kappa B activity and IL-1 beta signalling pathway. Moreover, zingerone might be the active component of ginger responsible for the amelioration of colitis induced by TNBS. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据