期刊
FOOD CHEMISTRY
卷 136, 期 1, 页码 160-163出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.07.111
关键词
Green kiwifruit (Actinidia deliciosa); Gold kiwifruit (Actinidia chinensis); Sleep-inducing effect; GABA(A)-benzodiazepine receptor; Flavonoid
资金
- Riddet Institute, Massey University, New Zealand
Kiwifruit is one of the most popular fruits worldwide, and it has various biological properties, including antioxidant, anti-allergic, and cardiovascular protective effects. The peel of kiwifruit, which is a by-product of processing, is a good source of flavonoids; however, its bioactivity has not been widely investigated. In this study, we evaluated the hypnotic effects of green (GRPE, Actinidia deliciosa) and gold (COPE, Actinidia chinensis) kiwifruit peel ethanol extracts and their solvent fractions, and the possible underlying mechanisms. Oral GRPE and COPE administration (125-1000 mg/kg) produced a dose-dependent decrease in sleep latency and an increase in sleep duration in pentobarbital-treated mice. Among three different solvent fractions of GRPE and COPE, ethyl acetate (EA) fractions had the greatest effect on sleep duration at 250 mg/kg. The total flavonoid contents of solvent fractions were proportional to sleep duration. Like diazepam (a GABA(A)-benzodiazepine (BZD) receptor agonist), the hypnotic effects of GRPE, COPE, and their EA fractions were fully inhibited by flumazenil (a GABA(A)-BZD receptor antagonist). These results suggest that potentiation effects of GRPE and COPE on pentobarbital-induced sleep in mice may be modulated by a GABAergic mechanism. (C) 2012 Elsevier Ltd. All rights reserved.
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