期刊
FOOD CHEMISTRY
卷 132, 期 1, 页码 295-300出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2011.10.080
关键词
Nortriterpene glycoside; Triterpene glycoside; Antifungal activity; Sea cucumber; Apostichopus japonicas
资金
- Natural Science Foundation of China [30873200, 41176125]
- Shanghai Leading Academic Discipline Project [B906]
- Shanghai Pujiang Program [PJ2008]
A nortriterpene glycoside, 26-nor-25-oxo-holotoxin A(1) (1), four triterpene glycosides, including both holostane and non-holostane types analogues, holotoxins D-G (2-5), together with three known triterpene glycosides, holotoxins A(1) and B (6, 7), and cladoloside B (8), were isolated from the warty sea cucumber Apostichopus japonicus Selenka, a traditional tonic with high economic value in China. The structures of the new compounds were elucidated by a combination of detailed spectroscopic analysis and chemical methods. This is the first report of a nortriterpene glycoside isolated from sea cucumbers. These compounds showed potent antifungal activities in the in vitro biotest. A preliminary structure-activity analysis suggests that the 18(20) lactone group and the Delta(25) terminal double bond may increase the activity. The component of the carbohydrate chain seems play an important role whereas the double bond transformation from Delta(9(11)) to Delta(7) in the aglycone moiety contributes little to the bioactivity. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据