期刊
FOOD CHEMISTRY
卷 135, 期 3, 页码 868-872出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.05.117
关键词
Marine red alga; Rhodomela confervoides; Bromophenol; Radical scavenging activity
资金
- National Natural Science Foundation of China [30530080]
- National Marine 863 Project [2007AA09Z443]
- Department of Science and Technology of Shandong Province [2006GG2205023]
In addition to nine known bromophenol derivatives, five new nitrogen-containing bromophenols were isolated from an ethyl acetate extract of the marine red alga Rhodomela confervoides. By using spectro-scopic methods, the structures of the new compounds were identified as 3-(2,3-dibromo-4,5-dihydroxybenzyl)pyrrolidine-2,5-dione (1), methyl 4-(2,3-dibromo-4,5-dihydroxybenzylamino)-4-oxobutanoate (2), 4-(2,3-dibromo-4,5-dihydroxybenzylamino)-4-oxobutanoic acid (3), 3-bromo-5-hydroxy-4-methoxybenzamide (4), and 2-(3-bromo-5-hydroxy-4-methoxyphenyl)acetamide (5). All of these bromophenols showed potent scavenging activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radicals, with IC50 values ranging from 5.22 to 23.60 mu M. These compounds also displayed moderate activity against ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonate) radicals, with Trolox Equivalent Antioxidant Capacity values (TEAC) ranging from 2.11 to 3.58 mM. The results obtained in this study demonstrate that the bromophenols obtained from R. confervoides may have potential application in food and/or pharmaceutical fields as natural antioxidants. (C) 2012 Elsevier Ltd. All rights reserved.
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